Title

Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles

Document Type

Article

Publication Date

2011

Publication Source

Tetrahedron

Volume

67

Issue

47

Inclusive pages

9134-9141

Publisher

Elsevier Ltd.

Peer Reviewed

yes

Abstract

An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach, an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermol. carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivs.

Disciplines

Chemistry

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