Title

A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification

Document Type

Article

Publication Date

2012

Publication Source

Tetrahedron Letters

Volume

53

Issue

46

Inclusive pages

6177-6181

Publisher

Elsevier

Peer Reviewed

yes

Abstract

We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields.

Keywords

Ugi-4CR; Trifluoroethanol; Sequential Ugi-4CR/trifluoroethyl esterification

Disciplines

Chemistry

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