Title

Visual Analysis of a Cardiovascular System Based on ECG and ABP Signals Using Evolvable Hardware Design

Document Type

Article

Publication Date

2011

Publication Source

Journal of Integrated Design and Process Science

Volume

15

Issue

4

Inclusive pages

49-84

Publisher

I O S Press

Place of Publication

Netherlands

ISBN/ISSN

1875-8959

Peer Reviewed

yes

Abstract

In this paper, visual data analysis was applied to raw medical data using probability theory to provide valuable information for preliminary diagnosis. The evolvable hardware design approach combined with information theory was applied to model an adaptive cardiovascular system. The cardiovascular system is modelled by a digital logic circuit based on ECG and ABP signal samples as input and output respectively. In our experiments, five patients' ECG and ABP data was chosen for the visual analysis. A user friendly GUI was demoed and the correlation of patient data was analyzed in the space and time domain. The digital circuit model was extrinsically evolved using genetic programming as the evolutionary algorithm and mutual information as the fitness function. In our experiments using MATLAB, we demonstrated that the data analysis could provide valuable information for preliminary diagnosis, and the proposed method could fit the input-output relationship as recorded samples piece-wise in which each piece contains monotonic input data. The model we proposed is a self reconfigurable digital circuit model based on input and output information. It's safe to conclude that the model is adaptive to changes based on different patient's unique ECG and ABP signals since the I/O information is also changed. Furthermore, a "divide and conquer" method was employed to get a more accurate piece-wise model. Experimental results show that the method is feasible, scalable, and promising as a personalized medical simulation tool.

Keywords

modelling, medical data visualization, evolvable hardware, information theory, combinational logic circuits

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