Title

Lymphocyte Capping in Limb-Girdle Muscular Dystrophy: Patients and Carriers in an Amish Isolate

Document Type

Article

Publication Date

7-1982

Publication Source

American Journal for Medical Genetics

Volume

12

Issue

3

Inclusive pages

255-269

DOI

10.1002/ajmg.1320120303

Abstract

We observed a decreased proportion of capped lymphocytes using polyvalent immunoglobulin and concanavalin-A as ligands in limb-girdle muscular dystrophy patients, obligate carriers, and individuals who are at-risk for being limb-girdle muscular dystrophy carriers. Using the proportion of capped cells as a parameter, we found there was overlap between the carrier and control range. However, we were able to estimate the risk of being a carrier in the Amish who have an increased prevalence of the limb-girdle muscular dystrophy gene.

Keywords

Limb-Girdle muscular dystrophy;lymphocyte capping;autosomal recessive inheritance

Disciplines

Mathematics

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