Robert J. Visalli
Department of Biology
Indiana University – Purdue University Fort Wayne
IPFW Sigma Xi (Scientific Research Honor Society) Student Research Competition
Known as the causative agent of genital herpes, HSV-2 infection affects half a billion people worldwide. When HSV-2 infects a host cell, the virus uses the host cell nucleic acid and protein synthesis machinery to replicate and assemble new viral particles. HSV-2, as well as the numerous other herpesviruses, have been shown to synthesize numerous immune modulation proteins. Some viral proteins work simultaneously to block interferon synthesis and its signaling effects.
Nnenna Ezeilo (2010).
The Herpes Simplex Virus Type-2 UL24 protein: A potential antagonist of the cellular interferon regulatory pathway.