2015 IPFW Student Research and Creative Endeavor Symposium



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Faculty Sponsor

Dr. Mohammad


Department of Chemistry

University Affiliation

Indiana University – Purdue University Fort Wayne


Serine proteases are protein digesting enzymes and are involved in processes such as digestion of proteins in the food, blood clotting, and activation of certain proteins and enzymes. The action of serine proteases is highly regulated. An unregulated action of serine proteases will be disastrous for an organism. The action of serine proteases is regulated by a class of proteins called serine protease inhibitors. Protease inhibitors bind with serine proteases like a substrate and temporarily inhibit their activity. In this research I have investigated the heat stability of serine protease inhibitors extracted from canary beans. My results show that canary bean inhibitors are exceptionally stable to heat and are not denatured at 100 degree C up to an hour. The results of this research suggest that consumption of beans can affect the digestion of dietary proteins by intestinal proteases.



Investigation of the Heat Stability of Serine Protease Inhibitors from Canary Beans

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Chemistry Commons