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Dr. Jaiyanth Daniel
Department of Biology
Indiana University – Purdue University Fort Wayne
Tuberculosis (TB) is an airborne and highly infectious disease caused by Mycobacterium tuberculosis (Mtb) which still poses a major health issue; just in 2013, the World Health Organization reported 9 million new cases of TB and about 1.5 million deaths due to it. The Mtb bacteria are very hard to target with regular antibiotics because they tend to go into a dormant stage. In order to be able to combat dormant Mtb or block its resuscitation from dormancy in the human body, it is necessary to first discover the pathways and genes involved in these processes. It has been shown that, during its dormant state, Mtb imports fatty acids from the human host, but the proteins involved are yet to be identified. Additionally, we identified an Mtb gene coding for a protein with significant amino acid identity to an energy-dependent translational control protein in Escherichia coli which aids in revival from stationary phase. Our study examines the role of a protein in influencing the transport of fatty acids in E.coli cells lacking their native fatty acid transport protein and in regulating the resuscitation, from stationary phase, of E. coli cells that lack the translational control protein. Findings from our study could enable the development of antibiotics targeted against the dormant pathogen.
Biology | Life Sciences
Reyes, Shelby and Daniel, Jaiyanth, "Expression of a mycobacterial protein potentially involved in resuscitation from dormancy and fatty acid transport" (2015). 2015 IPFW Student Research and Creative Endeavor Symposium. 58.