Lymphocyte Capping in Limb-Girdle Muscular Dystrophy: Patients and Carriers in an Amish Isolate
American Journal for Medical Genetics
We observed a decreased proportion of capped lymphocytes using polyvalent immunoglobulin and concanavalin-A as ligands in limb-girdle muscular dystrophy patients, obligate carriers, and individuals who are at-risk for being limb-girdle muscular dystrophy carriers. Using the proportion of capped cells as a parameter, we found there was overlap between the carrier and control range. However, we were able to estimate the risk of being a carrier in the Amish who have an increased prevalence of the limb-girdle muscular dystrophy gene.
Limb-Girdle muscular dystrophy;lymphocyte capping;autosomal recessive inheritance
P Bader, C Bender, M Creason, P Conn, and Douglas W. Townsend (1982).
Lymphocyte Capping in Limb-Girdle Muscular Dystrophy: Patients and Carriers in an Amish Isolate. American Journal for Medical Genetics.12 (3), 255-269.