Faculty Sponsor

George S. Mourad

Document Type



Department of Biology

University Affiliation

Indiana University – Purdue University Fort Wayne

IPFW Sigma Xi (Scientific Research Honor Society) Student Research Competition



A fluoroorotic acid (FOA)-resistant mutant was isolated in a screen of a mutagenized population of Arabidopsis thaliana. Genetic analysis revealed that FOA resistance was due to a nuclear recessive gene, for1-1. Assay of key regulatory enzymes of the de novo synthesis and salvage of pyrimidines as well as uptake studies using radiolabelled purines and pyrimidines showed that for1-1/for1-1 plants were specifically defective in the uptake of uracil or uracil-like bases.

Presentation Date


Included in

Biology Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.