George S. Mourad
Indiana University-Purdue University Fort Wayne
IPFW Sigma Xi (Scientific Research Honor Society) Student Research Competition
Screening of an EMS-mutagenized population of Arabidopsis thaliana has revealed a fluoroorotic acid (FOA)-resistant mutant. Genetic analysis has shown that FOA resistance was due to a nuclear recessive gene, for1-1. Assays of key regulatory enzymes of the de novo synthesis and salvage of pyrimidines, and also uptake studies using radiolabelled purines and pyrimidines have revealed that for1-1/for1-1 plants were defective in the uptake of free uracil and uracil-like bases.
Jaclyn N.M. Nguyen (2011).
Chromosome walking using Arabidopsis thaliana identifies a new locus affecting the inter- and intra-cellular transport of uracil.