Indiana University-Purdue University Fort Wayne
The blood-brain barrier (BBB) is both a metabolic and physical membrane that separates the central nervous system (CNS) from systemic circulation. Tight junction (TJ) proteins of vascular endothelial cells work in conjunction with astrocytes and pericytes to maintain the integrity of the BBB. Recent studies have shown that the degradation of the BBB after acute ischemic stroke is related to the inflammation and necrosis of brain tissue.
Thomas Easterday (2011).
Expression of intracellular adhesion molecules in ischemic tissue of the brain.